Manchester United come into the match on the back of a 1-0 defeat at Newcastle United in the Premier League on the weekend.
It was a disappointing performance from the Red Devils and they could easily have been losing at half time but it was 0-0.
Into the second half and Newcastle took just 10 minutes to score the only goal of the game.
The defeat at Newcastle means Manchester United have won only 2 of their 5 most recent fixtures in all competitions.
The wins came at home against Luton Town and away to Everton in the Premier League.
There was a 3-3 draw at Galatasaray in the Champions League and a 4-3 defeat at FC Copenhagen in the same competition.
Trends show Manchester United are unbeaten in 36 of their 41 most recent home matches in all competitions.
They have won 10 of their last 13 home Premier League games but have lost 3 of their 5 most recent Premier League matches on home soil.
Manchester United have kept only 1 clean sheet from their last 6 home Premier League games.
Chelsea make the trip to Old Trafford on the back of a 3-2 home win over Brighton in the Premier League on the weekend.
The Blues raced into a 2 goal lead inside the opening 21 minutes but Brighton pulled a goal back on the stroke of half time.
Chelsea were reduced to 10 men for the whole of the second half but restored their 2 goal advantage in the 65th minute. Brighton scored their second goal at the end of the game.
The win over Brighton means Chelsea are undefeated in 4 of their 5 most recent fixtures in all competitions.
There have been wins over Tottenham Hotspur away in the Premier League and Blackburn Rovers at home in the League Cup plus a 4-4 draw with Chelsea at home in the Premier League.
The only defeat came away to Newcastle United in the Premier League.
Trends show Chelsea have seen over 2.5 goals in their last 4 games in all competitions. They are undefeated in 4 of their last 5 away Premier League fixtures.
Team news: Manchester United continue without the injured quartet of Mason Mount, Christian Eriksen, Casemiro, and Lisandro Martínez.
There are also doubts over the fitness of Jonny Evans, Amad Diallo, and Tyrell Malacia.
Chelsea will be without suspended midfielder Conor Gallagher. Trevoh Chalobah is injured while Malo Gusto, Ben Chilwell, Roméo Lavia, Carney Chukwuemeka, and Christopher Nkunku are all working their way back to fitness.
Both teams were hoping for a better start to the season and have work to do to finish in the top four.
There are problems defensively for Manchester United and Chelsea, so both teams should score in this match, with home advantage perhaps being the deciding factor.
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